Endocrine Abstracts

Diabetic retinopathy remains the leading cause of blindness in the developed world resulting in significant morbidity for the diabetes population. As yet the specific pathogenesis remains elusive. Endogenous growth hormone (GH) is implicated in the development of retinal new vessels that characterize proliferative retinopathy. Both endogenous GH and its active protein, Insulin like growth factor-1 (IGF-1) have been found to be at high levels in diabetes, especially in patients...

Background: Central diabetes insipidus (DI) has now been described in a handful of case reports as a symptom of Covid-19 infection - associated with acute respiratory distress syndrome (ARDS)1 - and as a possible late onset sequela secondary to Covid-19 infection. It has also once been reported following immunization with mRNA Covid-19 vaccination. Our Trust serves a population of 612,000 and we have recently observed two cases of central DI, one post Covid-19 infection and on...

Hypercalcaemia is a recognised feature of hyperthyroidism due to accelerated bone turnover caused by thyroid hormone. When present, it is generally mild, usually with levels < 3.00 mmol/l. We present a case of a 19 year old male with thyrotoxicosis, who had severe hypercalcaemia and was also found to have possible co-existent adrenal insufficiency at the same time.He presented with a 4 month history of weight loss, anxiety, tremors and palpitations. ...

Current guidance recommends replacing vitamin D in patients with mild primary hyperparathyroidism although there are reports of worsening hypercalcaemia in some patients. Vitamin D replacement has also been known to cause hypercalcaemia in patients with sarcoidosis. We present a case of a patient with co-existent sarcoidosis and primary hyperparathyroidism, who developed severe hypercalcaemia following treatment with high dose Vitamin D.A 63 year old lad...